6 research outputs found
A Population Based Regional Dynamic Microsimulation of Germany: The MikroSim Model
- Author
- Publication venue
- DEU
- Publication date
- 01/01/2021
- Field of study
Microsimulation models are widely used to evaluate the potential effects of different policies on social indicators. Most microsimulation models in use operate on a national level, disregarding regional variations. We describe the construction of a national microsimulation model for Germany, accounting for local variations in each of the more than 10,000 communities in Germany. The database used and the mechanisms implementing the population dynamics are described. Finally, the further development of the database and microsimulation programs are outlined, which will contribute towards a research lab that will be made available to the wider scientific community
Entropically-driven ring-opening metathesis polymerization (ED-ROMP) of macrocyclic olefins prepared from deoxycholic acid to give functionalized polymers
- Author
- Abdel Chakiri
- Albertsson
- Albertsson
- Alexander
- Ben-Haida
- Brunelle
- Bryan
- Dalla Cort
- Ercolani
- Ercolani
- Gangwal
- Gautrot
- Gautrot
- Gautrot
- Gautrot
- Gautrot
- Gilbert
- Hall
- Hejl
- Hodge
- Hodge
- Hodge
- Hodge
- Hodge
- Höcker
- Ivanysenko
- Jacobson
- Jacobson
- Kamau
- Loewenthal
- Manzini
- Maravigna
- Ofstead
- Patel
- Philip Hodge
- Reichstein
- Ruddick
- Semlyen
- Strandman
- Strandman
- Suter
- Thorn-CsanĂ yi
- Trnka
- Wender
- Xue
- Zhu
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2015
- Field of study
Catalytic processing of plastic waste on the rise
- Author
- Achilias
- Aguado
- Akubo
- Al-Sabagh
- Al-Sabagh
- Al-Salem
- Ali
- Anuar Sharuddin
- Anwar
- Austin
- Azkaar
- Bae
- Balaraman
- Bartolome
- Behrendt
- Bhandari
- BlazsĂł
- Brooks
- Bryant
- Butler
- Campanelli
- Castillo
- Celik
- Chen
- Chen
- Chuayjuljit
- Coates
- Coriolano
- Elessawy
- Esquer
- European Union
- Evsyukov
- Fan
- Feng
- Fuentes
- Fukushima
- FĂĄvaro
- GarcĂa
- George
- Geyer
- Geyer
- Geyer
- Ghaemy
- Glas
- Glatzer
- Goje
- Gong
- Gong
- Gong
- Han
- Han
- Han
- Hashimoto
- Hu
- Hundertmark
- Höcker
- Imran
- Imran
- Jambeck
- Jehanno
- Jehanno
- Joo
- Kamau
- Kameda
- Kao
- Kawai
- Khalaf
- KijeĆiski
- Kim
- Kim
- Kleeberg
- Komly
- Krall
- Kunwar
- Kurokawa
- Lal
- Lee
- Lee
- Lopez
- Luo
- Mark
- Martin-Martinez
- Maschmeyer
- Meys
- Miandad
- Milina
- Moberg
- Mondelli
- Motokucho
- Munir
- Munir
- Murata
- MĂŒller
- Nakaji
- Neffgen
- Nikje
- Ogunjobi
- Owen
- Oya
- Palos
- Panda
- Pandey
- Philip
- Pingale
- Pohjakallio
- Quartinello
- Ragaert
- Raheem
- Rodrigues Fernandes
- Ronkvist
- Russ
- Ryberg
- Saadun
- Saadun
- Sangalang
- Scheirs
- Seino
- Senthil Kumar
- Sheel
- Siddiqui
- SimĂłn
- SimĂłn
- SimĂłn
- Singh
- Sinha
- Sohn
- Somoza-Tornos
- Song
- Suriapparao
- Taheri
- Tang
- Tang
- Tennakoon
- Then
- Thiounn
- Tokiwa
- Tomishige
- Tournier
- Tsiamis
- Tullo
- United States Environmental Protection Agency
- Usmani
- Van de Vyver
- Veregue
- Vertommen
- Vollmer
- Vorobyeva
- Wang
- Wang
- Wang
- Wei
- Wei
- Wei
- Westhues
- Woodley
- Wu
- Yang
- Yang
- Yang
- Yarulina
- Yoon
- Yoshida
- Yoshioka
- Yu
- Zhang
- Zhang
- Zhao
- Zhao
- Zheng
- Zhou
- Zhou
- ĂgdĂŒler
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Entropically Driven Ring-Opening Polymerization of Strainless Organic Macrocycles
- Author
- Alessi M.
- Allen G.
- Andrews J. M.
- Aquino E. C.
- Ast W.
- Bachrach A.
- Baxter I.
- Baxter I.
- Baxter I.
- Beeren S. R.
- Ben-Haida A.
- Ben-Haida A.
- Ben-Haida A.
- Ben-Haida A.
- Ben-Haida A.
- Ben-Haida A.
- Ben-Haida A.
- Berr C. E.
- Berti C.
- Bielawski C. W.
- Bosman A. W.
- Bouyahyi M.
- Boydston J.
- Brandrupp J.
- Brocchini S.
- Brunelle D. J.
- Brunelle D. J.
- Brunelle D. J.
- Brunelle D. J.
- Brunelle D. J.
- Brunelle D. J.
- Brunelle D. J.
- Bryant J. J. L.
- Bryant J. J. L.
- Burch R. R.
- Cacciapaglia R.
- Cai J.
- Cai J.
- Chamberlain B. M.
- Chan K. P.
- Chan K. P.
- Chen C.-W.
- Chen K.
- Chen K.
- Chen K.
- Chen M.
- Chen M.
- Chen M.
- Cheng C.
- Choon C. L.
- Colquhoun H. M.
- Colquhoun H. M.
- Colquhoun H. M.
- Colquhoun H. M.
- Colquhoun H. M.
- Colquhoun H. M.
- Conzatti L.
- Cook A.
- Cooper D. R.
- Corbett P. T.
- Cordova A.
- Dalla Cort A.
- Dalla Cort A.
- de Geus M.
- De Greef T. F. A.
- Ding Y.
- Ding Y.
- Dire C.
- Dong H.
- Dove A. P.
- Dove A. P.
- Duda A.
- Duda A.
- East G. C.
- Ercolani G.
- Ercolani G.
- Feng J.
- Fijten M. W. M.
- Fijten M. W. M.
- Flanigan E.
- Focarete M. L.
- FĂŒrstner A.
- Ganguly S.
- Gao W.
- Gautrot J. E.
- Gautrot J. E.
- Gautrot J. E.
- Gilbert R. G.
- Glans J. H.
- Goldring W. P. D.
- Gonzalez-Vidal N.
- Gonzalez-Vidal N.
- Gonzalez-Vidal N.
- Goodman I.
- Goodman I.
- Gross R. A.
- Grubbs R. H.
- Guerrero-Sanchez C.
- Guerrero-Sanchez C.
- Guo Q. Z.
- Hall A. J.
- Hall A. J.
- Hall A. J.
- Hamilton S. C.
- Harpp D. N.
- Hashimoto K.
- Hawkins R. T.
- Hejl A.
- Hill J. W.
- Hill J. W.
- Hill J. W.
- Hill J. W.
- Hodge P.
- Hodge P.
- Hodge P.
- Hodge P.
- Hodge P.
- Hodge P.
- Hodge P.
- Hodge P.
- Hodge P.
- Hruby V. J.
- Hubbard P.
- Hubbard P.
- Hulteen J. C.
- Hunt R. A. R.
- Höcker H.
- Höcker H.
- Höcker H.
- Höcker H.
- Illuminati G.
- Ivin K. J.
- Ivin K. J.
- Jacobson H.
- Jeong W.
- Jiang H.
- Jiang H.
- Jiang H.
- Jiang H.
- Jones D. J.
- Kamau S. D.
- Kamau S. D.
- Kamau S. D.
- Kamau S. D.
- Kameyama A.
- Kang S.
- Kato M.
- Kiesewetter M. K.
- Kim Y. H.
- Kim Y. H.
- Kim Y. J.
- Klaikherd A.
- Kobayashi S.
- Kobayashi S.
- Kobayashi S.
- Krafft F.
- Kricheldorf H. R.
- Kricheldorf H. R.
- Kricheldorf H. R.
- Laurent B. A.
- Lee C. W.
- Lee S.-S.
- Li Q.
- Liang Z.-A.
- Liebman J. F.
- Lim B.-H.
- Limer A.
- Litinas K. E.
- Manolakis I.
- Manzini B.
- Manzini B.
- Marsella M. J.
- Matson J. B.
- Matsumura S.
- Matyjaszewski K.
- Maynard H. D.
- Mecerreyes D.
- Meng Y. Z.
- Meng Y. Z.
- Michrowska A.
- Mohanraj S.
- Monfette S.
- Monvisade P.
- Monvisade P.
- MĂŒller S.
- Nagahata R.
- Nagahata R.
- Nagahata R.
- Namekawa S.
- Namekawa S.
- Namekawa S.
- Nomura K.
- Oae S.
- Ofstead E. A.
- Ohishi T.
- Okajima S.
- Okajima S.
- Osanai Y.
- Osanai Y.
- Peeters E.
- Peng P.
- Phan T. N. T.
- Philip Hodge
- Rendleman J. A.
- Rothe M.
- Rothe M.
- Ruddick C. L.
- Ruddick C. L.
- Ruggli P.
- Ruzicka L.
- Rzayev J.
- Semlyen J. A.
- Siriphannon P.
- Siriphannon P.
- Siriphannon P.
- Spanagel E. W.
- Spanagel E. W.
- Steinhart M.
- Strandman S.
- Suzuki M.
- Suzuki M.
- Tastard C. Y.
- Teasley M. F.
- Teasley M. F.
- Teasley M. F.
- Thorn-CsĂĄnyi E.
- Tripathy A. R.
- Tripathy A. R.
- Tsuchida E.
- Unciti-Broceta A.
- Van der Mee L.
- Van der Meulen I.
- Van der Meulen I.
- Veld M. A. J.
- Vermylen V.
- W. Memeger W.
- Walker R.
- Wang Y.-F.
- Wang Y.-F.
- Wang Y.-F.
- Wang Y.-F.
- Wang Y.-F.
- Wang Y.-F.
- Webster D. C.
- Wei K.-L.
- Wolovsky R.
- Wood B. R.
- Wood B. R.
- Xia Y.
- Xie D.
- Xie D.
- Xue Z.
- Yang H. H.
- Yang Y.
- Yoda K.
- Yokozawa T.
- Yoshino K.
- Yoshino K.
- You Y.-Z.
- Youk J. H.
- Youk J. H.
- Youk J. H.
- Zhang D.
- Zhang D.
- Zhong Z.
- Ziegler K.
- Zimmerman D. A.
- Zini E.
- Zolotukhin M. G.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Synthetic biology for the directed evolution of protein biocatalysts:navigating sequence space intelligently
- Author
- Abrahamson
- Abrahamson
- Abriata
- Acevedo-Rocha
- Acevedo-Rocha
- Adamczyk
- Adams
- Addington
- Afriat-Jurnou
- Agresti
- Agudo
- Aharoni
- Aharoni
- Aita
- Aita
- Aita
- Aita
- Aita
- Akanuma
- Akiva
- Akoh
- Alahuhta
- Albery
- Alcolombri
- Alexander
- Alexander
- Alexeeva
- Alexeeva
- Althoff
- Alvizo
- Amitai
- An
- An
- Ananiadou
- Ananiadou
- Ananiadou
- Anderson
- Anderson
- Anderson
- Andreeva
- Andreini
- Andrew Currin
- Anfinsen
- Anfinsen
- Ansari
- Antoniou
- Ao
- Araya
- Arkin
- Armstrong
- Armstrong
- Arnlund
- Arnold
- Arnold
- Arnold
- Arnold
- Ashani
- Ashlock
- Atkin
- Aucamp
- Aucamp
- Auerswald
- Axe
- Azuma
- Baas
- Babtie
- Babtie
- Bacardit
- Bae
- Bae
- Bahar
- Bai
- Bailey
- Baldi
- Baldwin
- Baldwin
- Bar-Even
- Barnett
- Bartlett
- Bashton
- Basner
- Bastolla
- Bastolla
- Beasley
- Becker
- Becker
- Beece
- Behrendorff
- Behrendorff
- Behrens
- Bellman
- Bellows
- Benkovic
- Benkovic
- Benson
- Berezovsky
- Bergquist
- Bernath
- Bernath-Levin
- Bernhardt
- Besenmatter
- Bhabha
- Bhan
- Bharat
- Bhattacharya
- Bhattacherjee
- Binder
- Binkowski
- Bishop
- Blomberg
- Bloom
- Bloom
- Bloom
- Bloom
- Bloom
- Bloom
- Blum
- Boehr
- Boersma
- Boersma
- Boersma
- Bolt
- Bommarius
- Borchert
- Bornscheuer
- Boros
- Borovkov
- Bos
- Bouvignies
- BoĆŸiÄ
- Bradley
- Bradley
- Bradley
- Bradley
- Braman
- Braun
- Bray
- Breen
- Breiman
- Breiman
- Brezovsky
- Bridgewater
- Broadhurst
- Bromley
- Bromley
- Brown
- Bruice
- Bruins
- Brustad
- Buchanan
- Buchanan
- Buer
- Buer
- Buer
- Burge
- Burger
- Burger
- Burton
- Buskirk
- Butler
- Buzan
- BĂ€ck
- Cadeddu
- Cadwell
- Cairns
- Callender
- Camarero
- Campbell
- Campodonico
- Camps
- Carbonell
- Carbonell
- Carbonell
- Carbonell
- Carey
- Carlson
- Carlson
- Carneiro
- Carr
- Carrea
- Caruthers
- Castle
- Caswell
- Chakraborty
- Chakraborty
- Chalmers
- Chan
- Chang
- Chang
- Chaparro-Riggers
- Chaparro-Riggers
- Chaput
- Chelliah
- Chelliah
- Chelliah
- Chen
- Chen
- Cheng
- Cherry
- Chiang
- Chica
- Chin
- Chin
- Cho
- Church
- Claren
- Cleveland
- Cochran
- Coco
- Coco
- Coco
- Coleman
- Cooper
- Copp
- Cormack
- Corne
- Cornish-Bowden
- Cosconati
- Courtois
- Courtot
- Crameri
- Csermely
- Csermely
- Csermely
- Csete
- Csete
- Cuff
- Cuff
- Cuff
- Culberson
- Cunningham
- Currin
- Cutler
- CĂĄzares
- Dach
- Dadusc
- Dalby
- Dalby
- Dalby
- Damborsky
- Damborsky
- Daniel
- Daugherty
- Daugherty
- Davey
- Davey
- Davids
- Davidson
- Davidson
- Davis
- Davydov
- Davydov
- De Ferrari
- de Juan
- de Kok
- De Mot
- de Visser
- Deb
- Dechancie
- Deechongkit
- del Sol Mesa
- Delagrave
- Dellus-Gur
- Deng
- Deng
- Deng
- Dennig
- Dennig
- DePristo
- Desai
- DeSantis
- Devenish
- Diaz
- Dictenberg
- Dietrich
- Dill
- DiMaio
- Dimova
- Dixon
- Dixon
- Doan
- Dobson
- Dobson
- Dobson
- Dobson
- Dobson
- Dokarry
- DomĂnguez de MarĂa
- Doshi
- Douglas B. Kell
- Doyle
- Doyle 3rd
- Drummond
- DĂaz
- DĂŒrrenberger
- Edgar
- Edwards
- Eiben
- Eiben
- Eisenbeis
- Elliott
- Endelman
- Engen
- Eppler
- Esswein
- Eun
- Faber
- Fallah-Araghi
- Farid
- Fasan
- Fasan
- Faulon
- Faver
- Featherstone
- Feigenbaum
- Feldmeier
- Feldwisch
- Fell
- Feng
- FernĂĄndez
- FernĂĄndez-Ălvaro
- Ferrada
- FerreirĂłs-MartĂnez
- Fersht
- Fersht
- Fersht
- Fialkowski
- Finkelstein
- Firth
- Firth
- Fischer
- Fischer
- Fischereder
- Fischlechner
- Fisher
- Fleishman
- Floor
- Floudas
- Fogel
- Foo
- Foo
- Forsyth
- Fowler
- Fowler
- Fowler
- Fowler
- Fowler
- Fowler
- Fox
- Fox
- Fox
- Fox
- Fox
- Fox
- Franke
- Franklin
- Frasch
- Frauenfelder
- Frauenfelder
- Frenken
- Friesner
- Frushicheva
- Frushicheva
- Frushicheva
- Fry
- Fu
- Fuglebakk
- Fuhrmann
- Fujii
- Fujii
- Fujii
- Furnham
- Fushan
- Fuxreiter
- Gabora
- Galdzicki
- Ganco
- Gao
- Gao
- Garcia-Ruiz
- Garcia-Seisdedos
- Garcia-Viloca
- Gatti-Lafranconi
- Gavira
- Gavish
- Gavish
- Gebauer
- Gebauer
- Geddie
- Geisendorf
- Gerlt
- Gerlt
- Geu-Flores
- Gherardini
- Ghislieri
- Gibson
- Gibson
- Giger
- Gillespie
- Gillespie
- Gimenez
- Giver
- Glenn
- Goldberg
- Goldberg
- Goldman
- Goldsmith
- Goldsmith
- Goldstein
- Gong
- Gonzalez-Lergier
- GonzĂĄlez
- Goodacre
- Gordeev
- Gordon
- Goswami
- Govindarajan
- Grant
- Graziano
- Greaves
- Greene
- Greenidge
- Greiner
- Gribble
- Griffiths
- Gront
- GrĂŒnberger
- Gu
- Guha
- Guha
- Guha
- Guha
- Guha
- Guha
- Gumulya
- Gunneriusson
- Gunneriusson
- Guo
- Gupta
- Gupta
- Gupta
- Gustafsson
- Haglund
- Halgren
- Hallen
- Halling
- Hamamatsu
- Hamamatsu
- Hammes
- Han
- Handl
- Handl
- Handl
- Handoko
- Hanf
- Happe
- Harms
- Harris
- Hartl
- Hasan
- Hashimoto
- Hastie
- Hatzimanikatis
- Hay
- Hay
- Hay
- Hay
- Hayashi
- He
- He
- He
- Hecht
- Hecht
- Heckman
- Heinisch
- Heinrich
- Heinzelman
- Heinzelman
- Heinzelman
- Henn-Sax
- Henry
- Henzler-Wildman
- Henzler-Wildman
- Henzler-Wildman
- Herman
- Herrera-Rodriguez
- Herrera-Rodriguez
- Herrgard
- HerrgÄrd
- Hetényi
- Hewitt
- Hewitt
- Hibbert
- Hibbert
- Hibbert
- Hickman
- Hidalgo
- Hidalgo
- Hilvert
- Ho
- Hodgson
- Hoebenreich
- Hoesl
- Hofrichter
- Hofrichter
- Hohlbaum
- Hokanson
- Holland
- Holliday
- Hollmann
- Hollmann
- Hollmann
- Holmquist
- Hopf
- Horton
- Huang
- Huang
- Huang
- Huang
- Huang
- Hucka
- Hughes
- Hughes
- Huisman
- Hult
- Humble
- Hunter
- Hunter
- Huynen
- Hvidsten
- Hyster
- Höcker
- Höcker
- Höcker
- Höhne
- Iijima
- Imanaka
- Iranzo
- Ishii
- Islam
- Ito
- Iwakura
- Jackson
- Jain
- JasiĆski
- Jeffery
- Jencks
- Jeon
- Jiang
- Jiang
- Jimenez-Roldan
- Jiménez
- Jiménez-Osés
- Jing
- Jochens
- Jochens
- Joern
- Johnson
- Jones
- Jones
- Jones
- Jones
- Jonsson
- Joo
- Jung
- Jurneczko
- JĂ€ckel
- JĂ€ckel
- Kacser
- Kacser
- Kai
- Kaldenhoff
- Kaltashov
- Kalyanaraman
- Kamerlin
- Kamerzell
- Kamtekar
- Kashiwagi
- Kauffman
- Kauffman
- Kauffman
- Kawarasaki
- Keefe
- Kegler-Ebo
- Keightley
- Keiser
- Keleti
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kell
- Kellogg
- Kelly
- Khare
- Khatib
- Khersonsky
- Khersonsky
- Khersonsky
- Khersonsky
- Khersonsky
- Khnykin
- Kikuchi
- Kikuchi
- Kikuchi
- Kikuchi
- Kille
- Kim
- Kim
- Kim
- Kintses
- Kintses
- Kipnis
- Kipnis
- Kirsch
- Kiss
- Kleinman
- Knight
- Knowles
- Knowles
- Knowles
- Knowles
- Knowles
- Koder
- Kohls
- Konermann
- Kosciolek
- Koudelakova
- Kourist
- Koza
- Koza
- Koza
- Koza
- Koza
- KraĆĄovec
- Kries
- Kronvall
- Kuhlman
- Kumar
- Kuroda
- Labas
- Lamb
- Langdon
- Langdon
- Lange
- Langton
- Lanthaler
- Lauchli
- Lauck
- Law
- Le NovĂšre
- Le NovĂšre
- Leaver-Fay
- Leconte
- Lee
- Lee
- Lee
- Leemhuis
- Lees
- Leferink
- Lehmann
- Lehmann
- Lehmann
- Lehmann
- Lennen
- Lennen
- Leonard
- Leopoldseder
- LeProust
- Leung
- Levin
- Lewell
- Lewis
- Lewis
- Li
- Li
- Li
- Li
- Liang
- Liang
- Liang
- Liao
- Lichtenstein
- Lidstrom
- Liebeton
- Lim
- Lin
- Lin
- Lin
- Lindberg
- Lindorff-Larsen
- Lindsay
- Ling
- Lipovsek
- Liu
- Liu
- Liu
- Liu
- Liu
- Liu
- Lo
- Loakes
- Lopes da Silva
- Lopez
- Low
- Lu
- Lu
- Luciani
- Lukk
- Lunzer
- Lunzer
- Luo
- Lutz
- Lutz
- Lutz
- Lynch
- Löfblom
- Lönneborg
- Ma
- Ma
- Ma
- Maggiora
- Maher
- Maheshwari
- Major
- Malisi
- Manning
- Mantion
- Marciano
- Marks
- Marks
- Mate
- Matsui
- Matsumura
- Matsuura
- Matsuura
- Matsuura
- Mattanovich
- Matthews
- Matzas
- Maugeri
- Maugeri
- Maynard Smith
- McAllister
- McCandlish
- McCullum
- McLaughlin Jr
- Medawar
- Medina-Franco
- Meister
- Mena
- Mendez
- Meyer
- Meyer
- Miao
- Miller
- Miller
- Miller
- Milo
- Minczuk
- Minervini
- Minshull
- Mirceta
- Mitchell
- Miyazaki
- Mizuno
- Moffet
- Mohamed
- Moore
- Moore
- Moore
- Mora-Pale
- Morcos
- Morley
- Morrison
- Mosberg
- Moschen
- Mundhada
- Murzin
- Muñoz
- MĂŒller
- MĂŒller
- Nachman
- Nagano
- Nagel
- Nakazawa
- Nam
- Natarajan
- Neil Swainston
- Ness
- Nestl
- Neumann
- Neuwald
- Neylon
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- Ăstman
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- 'Royal Society of Chemistry (RSC)'
- Publication date
- 15/12/2014
- Field of study
The amino acid sequence of a protein affects both its structure and its function. Thus, the ability to modify the sequence, and hence the structure and activity, of individual proteins in a systematic way, opens up many opportunities, both scientifically and (as we focus on here) for exploitation in biocatalysis. Modern methods of synthetic biology, whereby increasingly large sequences of DNA can be synthesised de novo, allow an unprecedented ability to engineer proteins with novel functions. However, the number of possible proteins is far too large to test individually, so we need means for navigating the âsearch spaceâ of possible protein sequences efficiently and reliably in order to find desirable activities and other properties. Enzymologists distinguish binding (K (d)) and catalytic (k (cat)) steps. In a similar way, judicious strategies have blended design (for binding, specificity and active site modelling) with the more empirical methods of classical directed evolution (DE) for improving k (cat) (where natural evolution rarely seeks the highest values), especially with regard to residues distant from the active site and where the functional linkages underpinning enzyme dynamics are both unknown and hard to predict. Epistasis (where the âbestâ amino acid at one site depends on that or those at others) is a notable feature of directed evolution. The aim of this review is to highlight some of the approaches that are being developed to allow us to use directed evolution to improve enzyme properties, often dramatically. We note that directed evolution differs in a number of ways from natural evolution, including in particular the available mechanisms and the likely selection pressures. Thus, we stress the opportunities afforded by techniques that enable one to map sequence to (structure and) activity in silico, as an effective means of modelling and exploring protein landscapes. Because known landscapes may be assessed and reasoned about as a whole, simultaneously, this offers opportunities for protein improvement not readily available to natural evolution on rapid timescales. Intelligent landscape navigation, informed by sequence-activity relationships and coupled to the emerging methods of synthetic biology, offers scope for the development of novel biocatalysts that are both highly active and robust
Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
- Author
- Abrahamson
- Abrahamson
- Abriata
- Acevedo-Rocha
- Acevedo-Rocha
- Adamczyk
- Adams
- Addington
- Afriat-Jurnou
- Agresti
- Agudo
- Aharoni
- Aharoni
- Aita
- Aita
- Aita
- Aita
- Aita
- Akanuma
- Akiva
- Akoh
- Alahuhta
- Albery
- Alcolombri
- Alexander
- Alexander
- Alexeeva
- Alexeeva
- Althoff
- Alvizo
- Amitai
- An
- An
- Ananiadou
- Ananiadou
- Ananiadou
- Anderson
- Anderson
- Anderson
- Andreeva
- Andreini
- Andrew Currin
- Anfinsen
- Anfinsen
- Ansari
- Antoniou
- Ao
- Araya
- Arkin
- Armstrong
- Armstrong
- Arnlund
- Arnold
- Arnold
- Arnold
- Arnold
- Ashani
- Ashlock
- Atkin
- Aucamp
- Aucamp
- Auerswald
- Axe
- Azuma
- Baas
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- Babtie
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- Bae
- Bahar
- Bai
- Bailey
- Baldi
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- Baldwin
- Bar-Even
- Barnett
- Bartlett
- Bashton
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- Bastolla
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- Becker
- Becker
- Beece
- Behrendorff
- Behrendorff
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- Benkovic
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- Bhattacherjee
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- Pedotti
- Pei
- Pei
- Peisajovich
- Pelis
- Peng
- Peng
- Peralta-Yahya
- Petersen
- Peterson
- Petrik
- Petros
- Pfleger
- Pfleger
- Philip J. Day
- Piana
- Piana
- Pingoud
- Pirngruber
- Pisliakov
- Planson
- Pleiss
- Plewczynski
- Poelwijk
- Poli
- Polizzi
- Pollegioni
- Polyak
- Popper
- Porro
- Pourmir
- Powell
- Preiswerk
- Pritchard
- Pritchard
- Pritchard
- Privett
- Prokop
- Prymula
- Pu
- Pudney
- Qi
- Qi
- Qian
- Qian
- Radcliffe
- Radestock
- Radzicka
- Rao
- Rasila
- Rathi
- Rauscher
- Rauscher
- Rausell
- Raval
- Ravikumar
- Reckermann
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reetz
- Reeves
- Reidys
- Reig
- Repasky
- Resetca
- Rhee
- Richmond
- Richter
- Rieseberg
- Rinaldi
- Rivkin
- Roberts
- Robin
- Robin
- Rockah-Shmuel
- Rockman
- Roehner
- Roiban
- Roiban
- Romero
- Romero
- Romero
- Rosenberg
- Rosenfeld
- Rosic
- Roth
- Rowe
- Rowe
- Rowe
- Rowles
- Ruff
- Ruff
- Rummer
- Runguphan
- Röthlisberger
- Saaem
- Sacks
- Sadowski
- Saftalov
- Sahoo
- Sakai
- Salter
- Samish
- Samland
- Sanchis
- Sandeep
- Sandström
- Santoro
- Sapsford
- Saraf
- Saraste
- Sardessai
- Sardessai
- Sattler
- Saunders
- Saven
- Savile
- Scalley-Kim
- Schlehuber
- Schmid
- Schmidt
- Schmidt-Dannert
- Schmidt-Dannert
- Schmidt-Goenner
- Schmitz
- Schofield
- Schomburg
- Schomburg
- Schrewe
- Schwab
- Schwartz
- Schwede
- Schöpfel
- Sebestova
- Seeman
- Seifert
- Seitz
- Sen
- Seyfang
- Shao
- Shao
- Shaw
- Shendure
- Shendure
- Shih
- Shim
- Shivange
- Shushanyan
- Shyu
- Siegel
- Siehl
- Siehl
- Sievers
- Sievers
- Silberg
- Silver
- Simms
- Simon
- Sirin
- Sitnitsky
- Sitnitsky
- Sjostrom
- Skerra
- Skerra
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Sniegowski
- Sniegowski
- Socha
- Soh
- Solé
- Somogyi
- Soskine
- Sriprapundh
- Stadlmayr
- Starrfelt
- Stebel
- Steffens
- Steiner
- Stemmer
- Stemmer
- Stemmer
- Sterner
- Sterner
- Stojanovic
- Stojanovic
- Strack
- Strafford
- Strohmeier
- Strömbergsson
- Stumpfe
- Stumpfe
- Stumpfe
- StĂŒrzenbaum
- Sullivan
- Sung
- Suzuki
- Swainston
- Swainston
- Sykora
- Syswerda
- Szendro
- SĂĄ-Pessoa
- SĂłvĂĄgĂł
- SĂŒel
- Tabuchi
- Tamerler
- Tanaka
- Tanaka
- Tanaka
- Tang
- Tang
- Tang
- Tantillo
- Tantillo
- Tao
- Tao
- Tapscott
- Taverna
- Taverna
- Taverna
- Tawfik
- Taylor
- Taylor
- Taylor
- Tee
- Terwilliger
- Thiele
- Thompson
- Thomson
- Throndset
- Throndset
- Tian
- Tian
- Tokuriki
- Tokuriki
- Tokuriki
- Tolmachev
- Tomatis
- Toogood
- Toogood
- Townsend
- Tracewell
- Tracy
- Trefzer
- Troll
- Trott
- Trudeau
- Turner
- Turner
- Turner
- Turner
- Turner
- Uchiyama
- Uchiyama
- Uchiyama
- Uchiyama
- Uchiyama
- Unckless
- Unsworth
- Urlacher
- Uttamchandani
- Vaidyanathan
- Vaidyanathan
- Valli
- van den Berg
- van der Meer
- van Leeuwen
- van Loo
- van Rossum
- Varadarajan
- Vass
- Verma
- Vick
- Vick
- Vidal-Mas
- Vieille
- Vieille
- Villalba
- Villiers
- Villiers
- Vitkup
- Voigt
- Voigt
- VĂĄzquez-Duhalt
- VĂĄzquez-Figueroa
- VĂĄzquez-Figueroa
- Wagner
- Wagner
- Waldron
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Wang
- Ward
- Ward
- Ware
- Warshel
- Wassermann
- Watkins
- Weaver
- Weaver
- Weaver
- Weaver
- Wedge
- Wedge
- Wegner
- Wei
- Wei
- Weigt
- Weinberger
- Weinreich
- Weiss
- Welch
- Wells
- Wells Jr.
- Wescott
- Wescott
- West
- Whited
- Whitehead
- Whitty
- Widersten
- Wierenga
- Wiersma-Koch
- Wijma
- Wijma
- Wijma
- Wilke
- Wilke
- Williams
- Williams
- Williams
- Windle
- Wingler
- Winkler
- Winter
- Winter
- Wintrode
- Wintrode
- Wittig
- Wolpert
- Wombacher
- Wong
- Wong
- Wong
- Wong
- Wong
- Wong
- Wong
- Wood
- Worth
- Worth
- Worth
- Wright
- Wu
- Wu
- Wu
- Wu
- Wu
- Wymore
- Xie
- Xie
- Xie
- Xie
- Xie
- Xiong
- Xiong
- Xiong
- Xiong
- Xu
- Xu
- Xu
- Xu
- Yamauchi
- Yanagida
- Yang
- Yang
- Yang
- Yang
- Yau
- Yazaki
- Ye
- Ye
- Yeh
- Yeh
- Yockey
- Yokobayashi
- Yoo
- Yoshikuni
- You
- Youngquist
- Yu
- Yuan
- Yuan
- Zaccolo
- Zalatan
- Zanghellini
- Zaugg
- Zeikus
- Zha
- Zhan
- Zhang
- Zhang
- Zhang
- Zhang
- Zhao
- Zhao
- Zhao
- Zheng
- Zheng
- Zheng
- Zheng
- Zheng
- Zhou
- Zhou
- Zhou
- Zhou
- Zilly
- Zinchenko
- Zitzler
- ZĂĄrate-PĂ©rez
- Ăstman
- Ăstman
- Ćwiderek
- Ć ali
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2015
- Field of study